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Return to the list of publicationsDiagnostic and prognostic values of non-invasive biomarkers of fibrosis in patients with alcoholic liver disease.
| Title | Diagnostic and prognostic values of non-invasive biomarkers of fibrosis in patients with alcoholic liver disease. |
|---|---|
| Year | 2008 |
| Journal | Hepatology |
| Author(s) | Naveau S, Gaudé G, Asnacios A, Agostini H, Abella A, Barri-Ova N, Dauvois B, Prévot S, Ngo Y, Munteanu M, Balian A, Njiké-Nakseu M, Perlemuter G, Poynard T. |
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Abstract
RESULTS: The diagnostic values of FibrometerA and Hepascore did not differ from that of FibroTest for advanced fibrosis (all AUROCs=0.83±0.03) and cirrhosis (FibroTest and FibrometerA =0.94±0.02, Hepascore=0.92±0.02), and were significantly greater than those of non-patented biomarkers (APRI, Forns, FIB4; P<0.01). In multivariate analysis the most significant was FibroTest (P=0.001), without independent diagnostic value for FibrometerA (P=0.19), and Hepascore (P=0.40). The prognostic values of FibroTest (AUROC for survival or non liver disease-related death =0.79±0.04), FibrometerA (0.80±0.04), Hepascore (0.78±0.04), did not differ from that of biopsy fibrosis staging (0.77±0.04). In multivariate analysis the most significant were FibroTest (P=0.004) and biopsy (P=0.03), without independent prognostic values for FibrometerA (P=0.41) and Hepascore (P=0.28).
Complete reference
Naveau S, Gaudé G, Asnacios A, Agostini H, Abella A, Barri-Ova N, Dauvois B, Prévot S, Ngo Y, Munteanu M, Balian A, Njiké-Nakseu M, Perlemuter G, Poynard T. Diagnostic and prognostic values of non-invasive biomarkers of fibrosis in patients with alcoholic liver disease. Hepatology 2008; in press